I am currently focusing a majority of my web efforts towards DotNetNuke (DNN).  DNN is a Database driven web application framework for content management.  The great thing about DNN is its ability to be extended, both functionally and visually.
 

Visually:

DNN uses "Skins" to define the look of a web site.  These skins are separate from the content.  You can find many skins available for free or for purchase on the web.  If you have a skin you like, I can work with you to adjust it to your needs.
 

Let me say up front, that I am NOT a graphics designer.  At this point, I don't plan on being one anywhere in the near future.  BUT... if you have a layout you like, and want to use it with DNN, let me know and I can create a skin based on your layout reqirements.
 

Functionally:

DNN functionality can be extended by the use of modules.  Once again, there are many modules available for free and purchase on the internet (Click the SnowCovered Link on my home page!).  If these modules do not suit you, then I can create a module to suit your needs.